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Rat Ldlr cDNA Clone(NM_175762.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR014870

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Gene Information

Cat. No. CDFR014870
Description NativeORF clone of Rattus norvegicus low density lipoprotein receptor (Ldlr) as transfection-ready DNA NM_175762.2
Product Type cDAN Clone
Gene Abbr Ldlr
Species Rat
Vector pCMV6Entry
Target Gene LDLR
Background The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
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