Human NOTCH1 lentiviral particles

Name: Human NOTCH1 lentiviral particles
SKU: LV00401Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : LV00401Z

Storage : -80℃ Shipping : Frozen on dry ice

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Cat. No.	LV00401Z
Description	Human NOTCH1 ORF cDNA is cloned into the lentiviral expression vector for maximal stable delivery. The ready-to-use lentiviruses accelerate experiments investigating exogenous gene overexpression phenotypes and downstream molecular impacts.
Product Type	Lentiviral particle
Gene	NOTCH1
Species	Human
Titer	Varies lot by lot, for example, ≥110^7 TU/mL, ≥110^8 TU/mL, ≥1*10^9 TU/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality lentivirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between lentivirus particle lots.
Mycoplasma	Creative Biogene routinely tests for mycoplasma contamination using a mycoplasma detection kit. Cell lines are maintained for approximately 20 passages before being discarded and replaced with a new vial of early passage cells. Approximately 2 weeks after thawing, cell culture supernatants are tested for mycoplasma contamination. Creative Biogene ensures that lentiviral products are free of mycoplasma contamination.
Purity	Creative Biogene evaluates the level of impurities, such as residual host cell DNA or proteins, in prepared lentiviral vectors to ensure they meet quality standards.
Sterility	The lentiviral samples were inoculated into cell culture medium for about 5 days and the growth of bacteria and fungi was tested. Creative Biogene ensures that the lentiviral products are free of microbial contamination.
Transducibility	Upon requirement, Creative Biogene can perform in vitro or in vivo transduction assays to evaluate the ability of lentivirus to deliver genetic material into target cells, and assess gene expression and functional activities.
Proviral Identity Confirmation	All Creative Biogene lentiviral vectors are confirmed to have correctly integrated provirus using PCR. This test involves transducing cells with serial dilutions of the lentiviral vector, harvesting the cells a few days later, and isolating genomic DNA. This DNA is then used as a template to amplify a portion of the expected lentiviral insert.

Gene Name	NOTCH1 notch 1 [ Homo sapiens ]
Gene Symbol	NOTCH1
Synonyms	hN1; TAN1
Gene Description	Notch homolog 1, translocation-associated (Drosophila)
GeneID	4851
Uni ProtID	P46531
mRNA Refseq	NM_017617.3
Protein Refseq	NP_060087.3
Chromosome Location	9q34.3
Function	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; calcium ion binding; core promoter binding; enzyme binding; enzyme inhibitor activity; protein binding; receptor activity; sequence-specific DNA binding transcription factor activity;
Pathway	Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
MIM	190198

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Zhao C, Yang F, Wei X, et al. miR‐139‐5p upregulation alleviated spontaneous recurrent epileptiform discharge‐induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway[J]. Cell Biology International, 2021, 45(2): 463-476.

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Human NOTCH1 lentiviral particles

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