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NOTCH1


Official Full Name
notch receptor 1
Organism
Homo sapiens
Gene ID
4851
Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Synonyms
hN1; AOS5; TAN1; AOVD1

Cat.No. Product Name Price
SHH353820 shRNA set against Mouse NOTCH1 (NM_008714.3) Inquiry
SHR008426 shRNA set against Rat Notch1(NM_001105721.1) Inquiry
SHH218005 shRNA set against Human NOTCH1(NM_017617.3) Inquiry
SHW001162 shRNA set against Chicken NOTCH1 (NM_001030295) Inquiry
Cat.No. Product Name Price
CDFR005312 Rat Notch1 cDNA Clone(NM_001105721.1) Inquiry
MiUTR1H-06853 NOTCH1 miRNA 3'UTR clone Inquiry
MiUTR1M-07748 NOTCH1 miRNA 3'UTR clone Inquiry
MiUTR1R-04237 NOTCH1 miRNA 3'UTR clone Inquiry
SKO0104 NOTCH1 Validated sgRNA vector Inquiry
CDCB162637 Chicken NOTCH1 ORF Clone (NM_001030295) Inquiry
CDCL185502 Mouse NOTCH1 ORF clone(NM_008714.3) Inquiry
CDCR371903 Rat Notch1 ORF Clone(NM_001105721.1) Inquiry
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