Panoply™ Human NOTCH1 Knockdown Stable Cell Line

Name: Panoply™ Human NOTCH1 Knockdown Stable Cell Line
SKU: CSC-DC010514
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC010514

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC010514
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	NOTCH1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NOTCH1 notch 1 [ Homo sapiens ]
Gene Symbol	NOTCH1
Synonyms	hN1; TAN1
Gene Description	Notch homolog 1, translocation-associated (Drosophila)
GeneID	4851
Uni ProtID	P46531
mRNA Refseq	NM_017617.3
Protein Refseq	NP_060087.3
Chromosome Location	9q34.3
Function	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; calcium ion binding; core promoter binding; enzyme binding; enzyme inhibitor activity; protein binding; receptor activity; sequence-specific DNA binding transcription factor activity;
Pathway	Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
MIM	190198

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