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Cat.No. : CSC-RO0151 Host Cell: CHO-K1
| Cat. No. | CSC-RO0151 |
| Description | This cell line stably expresses human Fc fragment of IgG receptor and transporter (FCGRT). The surface expression of the target protein in CHO-FCGRT stable cells was analyzed via flow cytometry. |
| Gene | FCGRT |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Applications | Binding assay |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human FCGRT Stable Cell Line-CHO is derived from Chinese Hamster Ovary (CHO) cells, which are widely used in biotechnology for their ability to produce complex proteins. The cells are genetically engineered to stably express the full-length human FCGRT gene, which encodes the FcRn receptor. This process typically involves the use of a vector containing the FCGRT gene, which is then integrated into the CHO cell genome, allowing for the stable expression of the protein.
A: The genotype of the Human FCGRT Stable Cell Line-CHO includes the native CHO cell genome, supplemented with the exogenously introduced human FCGRT gene. The phenotype is characterized by the stable expression of the FcRn receptor on the cell surface, which can be confirmed by immunofluorescence or flow cytometry assays.
A: The Human FCGRT Stable Cell Line-CHO is used in various research areas, including immunology, pharmacology, and infectious disease studies. It is particularly valuable for studying the interaction of FcRn with immunoglobulins, therapeutic proteins, and viruses, as well as for the development and optimization of monoclonal antibodies and other biologics.
A: The use of Human FCGRT Stable Cell Line-CHO must adhere to guidelines set forth by institutional review boards and relevant regulatory bodies. This includes ensuring the cells are sourced ethically, used responsibly, and disposed of in an environmentally sound manner. Researchers must also follow good laboratory practices and comply with any specific regulations regarding genetically modified organisms.
A: The Human FCGRT Stable Cell Line-CHO is instrumental in the development of therapeutic proteins and vaccines, particularly those that require FcRn-mediated processes. It can be used to study the stability, half-life, and pharmacokinetics of these molecules, as well as to optimize their design for improved efficacy and safety.
A: The Human FCGRT Stable Cell Line-CHO can be used to investigate the binding and uncoating mechanisms of viruses like echoviruses, which rely on FcRn for entry into host cells. This can provide insights into viral pathogenesis and inform the development of antiviral strategies.
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