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Pseudo-UTP

For research use only. Not intended for any clinical use.
Cat.No.
RSNK-018
Description
Pseudo-UTP could be used to develop drugable mRNAs. Replacing the standard bases by modified ones can enhance their translation properties while reducing the immunogenicity.
Alias
Ψ-UTP, Pseudouridine-5'-Triphosphate
Applications
In vitro transcription
Molecular Formula
C9H15N2O15P3
Molecular Weight
484.1
Purity
≥95%
Size/Form
1 µmol, 5 µmol
Storage
Store at -20°C.

Publications

Q & A

Customer Reviews

Customer Q&As
What is Pseudouridine-5'-Triphosphate?

A: Pseudouridine-5'-triphosphate (ΨTP or Pseudo-UTP) is a modified nucleoside triphosphate that contains a "pseudo" or "false" uridine base. It is used as a substrate for RNA polymerases to incorporate Ψ into RNA during transcription.

What is Ψ?

A: Ψ is the most common modified nucleoside found in RNA, and it is formed by converting uridine (U) via an isomerization reaction.

What are the functions of Ψ?

A: Ψ has been shown to play an important role in RNA structure and function, as it can enhance stability and regulate gene expression.

What is the difference between uridine and pseudouridine?

A: Uridine contains a nitrogenous base called uracil, while pseudouridine contains a modified form of uridine. In pseudouridine, the carbon-carbon bond between the ribose sugar and the nitrogenous base is modified, which results in a slightly different chemical structure.

What are the functions of pseudouridine?

A: In RNA, pseudouridine can help stabilize the structure of molecules and participate in various functions, including splicing, translation, and RNA degradation.

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Customer Reviews
Effective tool

Incorporation of ΨTP into RNA transcripts has been shown to improve translation efficiency of the RNA.

United States

01/12/2020

Worked Very Well

Great buy! ΨTP incorporation into RNA transcripts can enhance the accuracy of translation by reducing frameshift errors.

United States

04/11/2021

Useful tool

I like it. Unmodified RNA can stimulate the immune system and trigger an inflammatory response, whereas ΨTP-modified RNA is less likely to elicit an immune response.

United States

11/21/2021

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