Poly (A) Tailing Kit

Name: Poly (A) Tailing Kit
SKU: RSNK-002
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RSNK-002

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Product Information

Cat. No.	RSNK-002
Description	Poly (A) Tailing Kit is a set of reagents designed to add a ≥150 base poly (A) tail to RNA transcripts generated with the T7 High Yield RNA Synthesis Kit.
Applications	In vitro transcription
Size	25 rxns
Storage	Store at -20°C.

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Customer Reviews

Customer Q&As

What is poly(A) tail?

A: Poly(A) tailing, also known as polyadenylation, is a post-transcriptional modification of eukaryotic mRNA (messenger RNA) molecules, in which a sequence of adenosine (A) nucleotides is added to the 3' end of the mRNA.

What does adding a poly(A) tail do?

A: Adding a poly(A) tail involves the addition of a long sequence of adenosine nucleotides to the 3' end of an mRNA molecule. The poly(A) tail is added in a process called polyadenylation, and it plays several important roles in mRNA stability, translation, and transport.

How does the poly(A) tail affect mRNA stability?

A: The poly(A) tail protects the mRNA molecule from enzymatic degradation. Without a poly(A) tail, mRNA molecules would be rapidly degraded by exonucleases, which are enzymes that cleave off nucleotides from the end of a molecule. The poly(A) tail also helps to recruit specific RNA-binding proteins that stabilize the mRNA molecule.

Is a longer poly(A) tail more stable?

A: At the end of each mRNA molecule is a poly(A) tail comprised of tens to hundreds of nucleotides called adenosines. The length of these tails can vary greatly between different mRNAs, and longer poly(A) tails are believed to improve translation and enhance mRNA stability.

Does poly(A) tail increase translation?

A: The poly(A) tail can also stimulate translation and cooperates with the cap structure in a synergistic fashion.

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Customer Reviews

Improve translation efficiency

Using this kit can improve translation efficiency in vivo. I recommend it.

United States

2022-06-16

Convenient

ThePoly (A) Tailing Kit can adjust the reaction to control tail length. Very convenient.

United States

2023-01-12

Great kit.

Great kit. In my micro injection and transfection experiments, the kit helped me improve the translation efficiency of cap RNA synthesized in vitro.

United States

2023-03-31

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Poly (A) Tailing Kit

Product Information

Q & A

Customer Reviews

What is poly(A) tail?

What does adding a poly(A) tail do?

How does the poly(A) tail affect mRNA stability?

Is a longer poly(A) tail more stable?

Does poly(A) tail increase translation?

Improve translation efficiency

Convenient

Great kit.

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