TREX1 Easy KO Kit (Human)

Name: TREX1 Easy KO Kit (Human)
SKU: CC-1466
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CC-1466

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Product Information

Gene Information

Cat. No.	CC-1466
Description	A complete kit for efficient gene knockout in mammalian cells, combining chemically synthesized sgRNAs with Cas9 RNPs to induce targeted DNA cleavage and generate frameshift mutations or deletions. All essential reagents for transfection and knockout validation are included for rapid, high-efficiency gene disruption.
Gene Abbr	Trex1
Gene Name	TREX1 three prime repair exonuclease 1 [ Homo sapiens ]
Species	Human
EnsemblID	ENSMUSG00000049734
NCBIGeneID	22040
Uni ProtID	Q91XB0
Features	All-in-One workflow from gene editing to knockout validation for users with no prior experience. Pre-validated sgRNAs and primers for rapid setup. Streamlined experiment handling. CRISPR RNP method ensures precise and efficient gene knockout.
Applications	This kit enables in vitro gene knockout in human-derived cells using chemically synthesized sgRNAs and Cas9-gRNA RNP complexes. Transfected RNPs cleave early exons of the target gene, inducing deletions or frameshift mutations for efficient and rapid knockout.
Reactions	5–10 reactions per target gene
Kit Components	2–3 chemically synthesized sgRNAs (200pmol each) 3 PCR/Sequencing primers (500pmol each) LM cell lysate (500µL) Cas9 protein (12µg) LM RNP transfection reagent (50µL)
Storage	Store at -80°C for up to 1 year or at -20°C for up to 6 months. Avoid repeated freeze-thaw cycles.

Gene Name	TREX1 three prime repair exonuclease 1 [ Homo sapiens ]
Gene Symbol	TREX1
Synonyms	TREX1; three prime repair exonuclease 1; AGS1, Aicardi Goutieres syndrome 1; DRN3; DNase III; 3 repair exonuclease 1; 3-5 exonuclease TREX1; CRV; AGS1; HERNS; DKFZp434J0310;
GeneID	11277
Uni ProtID	Q9NSU2
mRNA Refseq	BC023630
Chromosome Location	3p21.31
Function	3-5 exonuclease activity; 3-5 exonuclease activity; 3-5-exodeoxyribonuclease activity; MutLalpha complex binding; MutSalpha complex binding; adenyl deoxyribonucleotide binding; double-stranded DNA binding; exodeoxyribonuclease III activity; hydrolase activity; metal ion binding; metal ion binding; nucleic acid binding; protein homodimerization activity; protein homodimerization activity; single-stranded DNA binding;
Pathway	Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem;
MIM	606609

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