Recombinant Mouse Tnfsf15 (Tag free)

Name: Recombinant Mouse Tnfsf15 (Tag free)
SKU: RP00577
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00577 Tag : Tag free

Expressed Region : Ile76-Leu252 Expression System : E.coli

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Product Information

Gene Information

Cat. No.	RP00577
Description	Recombinant Mouse Tnfsf15 (Tag free) is produced in our E.coli expression system. The amino acid region expressed is Ile76-Leu252 without tag.
Species	Mouse
Tag	Tag free
Mol Weight	20 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Ile76-Leu252
Expression System	E.coli
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH 7.0.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	Tnfsf15
Synonyms	Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI

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Background

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Customer Reviews

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

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