Mouse Tnfsf15 ORF clone (NM_177371.3)

Name: Mouse Tnfsf15 ORF clone (NM_177371.3)
SKU: CDCH093620
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH093620

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Product Information

Gene Information

Cat. No.	CDCH093620
Description	Mus musculus tumor necrosis factor (ligand) superfamily, member 15 (Tnfsf15), mRNA.
Product Type	ORF clone
Gene Abbr	Tnfsf15
Species	Mouse
ORF Size	813bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

TNFSF15

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

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