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Cat.No. : RP00046 Tag: Tag free
Expressed Region: Tyr29-Gln159 Expression System: E.coli
| Cat. No. | RP00046 |
| Description | The Recombinant Human TSLP is produced in our E.coli expression system. The amino acid region expressed is Tyr29-Gln159 without tag. |
| Species | Human |
| Tag | Tag free |
| Mol. Weight | 15.1 KDa |
| Expressed Region | Tyr29-Gln159 |
| Expression System | E.coli |
| Format | Powder |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Conjugate | Unconjugated |
| Endotoxin Level | < 1 EU/µg of protein by LAL method |
| Purity | >95% as determined by SDS-PAGE. >90% as determined by SEC-MALS. |
| Shipping | The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles. |
| Reconstitution | Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Target Gene | TSLP |
| Background | This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. |
| Synonyms | Thymic stromal lymphopoietin; TSLP |
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