Biotinylated Cynomolgus TSLP (C-6His-Avi)

Name: Biotinylated Cynomolgus TSLP (C-6His-Avi)
SKU: RP00088

Cat.No. : RP00088 Tag: C-6His-Avi

Expressed Region: Tyr29-Gln159 (Arg127Ala, Arg130Ser) Expression System: Human Cell

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Cat. No.	RP00088
Description	The Biotinylated Cynomolgus TSLP (C-6His-Avi) is produced in our Human Cell expression system. The amino acid region expressed is Tyr29-Gln159 (Arg127Ala, Arg130Ser) with a 6His-Avi tag at the C terminus.
Species	Cynomolgus
Tag	C-6His-Avi
Mol. Weight	17.7 KDa
Expressed Region	Tyr29-Gln159 (Arg127Ala, Arg130Ser)
Expression System	Human Cell
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH7.4.
Conjugate	Biotin
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	TSLP
Background	This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants.
Synonyms	Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP

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