Recombinant Human MET (C-Fc)

Name: Recombinant Human MET (C-Fc)
SKU: RP00596
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00596 Tag : C-Fc

Expressed Region : Glu25-Thr932 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00596
Description	Recombinant Human MET (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Glu25-Thr932 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	128.4 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Glu25-Thr932
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	MET
Synonyms	Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET

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This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

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