Rat MET ORF clone(NM_031517.1)

Name: Rat MET ORF clone(NM_031517.1)
SKU: CDCL185325
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL185325

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Product Information

Gene Information

Cat. No.	CDCL185325
Description	ORF Clone of Rattus norvegicus met proto-oncogene (hepatocyte growth factor receptor) DNA.
Product Type	ORF clone
Gene Abbr	MET
Species	Rat
ORF Size	4149bp
Vector	pMD18-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

MET

Background

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

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