Recombinant Human CD276 (2Ig, C-Fc)

Name: Recombinant Human CD276 (2Ig, C-Fc)
SKU: RP00477
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00477 Tag : C-Fc

Expressed Region : Leu29-Pro245 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00477
Description	Recombinant Human CD276 (2Ig, C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Leu29-Pro245 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	50.2 KDa
Format	Powder
Expressed Region	Leu29-Pro245
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	CD276
Synonyms	CD276; 2Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule

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The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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