Lipopolysaccharides from S. minnesota R5

Name: Lipopolysaccharides from S. minnesota R5
SKU: VAR-017

For research use only. Not intended for any clinical use.

Cat.No.

VAR-017

Description

Lipopolysaccharide (LPS) is a natural adjuvant synthesized by gram-negative bacteria. LPS and its lipid A moiety can stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Product Type

Bacteria-derived Adjuvant

Purity

≥99%

Stability

Stable for at least 2 years after receipt when stored at 4°C.

Storage

Store at 4°C;

Publications

Q & A

Customer Reviews

Customer Q&As

In the preparation process of Lipopolysaccharides from S. minnesota R5, are specific culture conditions employed to ensure high-quality product?

A: Yes, in the preparation of Lipopolysaccharides from S. minnesota R5, specific culture conditions are typically used to ensure a high-quality product. This includes controlling parameters such as culture temperature, pH, and culture duration.

What are the common applications of Lipopolysaccharides from S. minnesota R5 in immunocellular research, and how do these applications contribute to our understanding of the immune system?

A: Lipopolysaccharides from S. minnesota R5 are commonly used to activate immune cell lines such as macrophages and dendritic cells to simulate immune responses. This helps study the activation of immune cells, cell signaling, and cytokine production processes, contributing to a better understanding of the immune system's functions.

When conducting cell research using Lipopolysaccharides from S. minnesota R5, how is the optimal concentration and treatment duration determined to obtain reliable experimental results?

A: Determining the optimal concentration and treatment duration for Lipopolysaccharides from S. minnesota R5 typically requires preliminary experiments and optimization. This includes conducting experiments at different concentrations and treatment durations to determine the best conditions for obtaining reliable experimental results.

Does Lipopolysaccharides from S. minnesota R5 exhibit varying immunoreactivity in different types of cell lines, and how might this diversity affect research outcomes?

A: Lipopolysaccharides from S. minnesota R5 may demonstrate varying immunoreactivity in different types of cell lines. This diversity can potentially affect the interpretation and generalization of research results. Therefore, experiments in different cell lines are necessary to understand its effects.

How is the endotoxic effect of Lipopolysaccharides from S. minnesota R5 handled to mitigate adverse effects on cells when using it?

A: To reduce the endotoxic effect of Lipopolysaccharides from S. minnesota R5 on cells, methods such as endotoxin removal or neutralization are typically employed. This may include heat treatment, affinity chromatography, or the use of endotoxin-neutralizing agents to minimize the impact of endotoxins on cells.

What are the potential areas of application for Lipopolysaccharides from S. minnesota R5 in clinical research, and are there known safety issues in its clinical use?

A: Lipopolysaccharides from S. minnesota R5 may have potential application areas in clinical research, such as immunotherapy. However, more clinical studies are needed to assess its safety and potential adverse reactions. Known endotoxic effects may lead to serious adverse effects, necessitating measures to mitigate risks in its clinical use.

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