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Human FCGR1A Stable Cell Line - CHO-K1

For research use only. Not intended for any clinical use.

Cat. No. :   CSC-RO0470

Host Cell :   CHO-K1 Size :   >1x106 frozen cells/vial

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Gene Information

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Cat. No. CSC-RO0470
Description This cell line is derived from CHO-K1 and is engineered to stably overexpress Human FCGR1A.
Target Gene FCGR1A
Gene Species Homo sapiens (Human)
Host Cell CHO-K1
Host Cell Species Cricetulus griseus (Chinese hamster)
Applications

1. Studying the interactions between immune cells and cancer cells

2. Studying the mechanisms of resistance to immune checkpoint blockade

3. High-throughput screening

4. Drug target validation

Size >1x106 frozen cells/vial
Stability Validated for at least 10 passages
Quality Control Negative for bacteria, yeast, fungi and mycoplasma.
Storage Liquid nitrogen
Shipping Dry ice
Revival Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Mycoplasma Negative
Format One frozen vial containing millions of cells
Storage Liquid nitrogen
Safety Considerations The following safety precautions should be observed.
1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum.
2. No eating, drinking or smoking while handling the stable line.
3. Wash hands after handling the stable line and before leaving the lab.
4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells.
5. All waste should be considered hazardous.
6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship Dry ice
Gene Name FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) [ Homo sapiens ]
Gene Symbol FCGR1A
Synonyms CD64; FCRI; CD64A; IGFR1
Gene Description Fc fragment of IgG, high affinity Ia, receptor (CD64)
Gene ID 2209
Uni Prot ID P12314
m RNA Refseq NM_000566.3
Protein Refseq NP_000557.1
Chromosome Location 1q21.2-q21.3
Function IgG binding; protein binding; receptor signaling protein activity;
Pathway Adaptive Immune System, organism-specific biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem;
MIM 146760
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