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Rat Nr1h3 ORF Clone(NM_031627.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379784

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Gene Information

Cat. No. CDCR379784
Product Type ORF Clone
Gene Abbr Nr1h3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1338 bp
Vector pCMV6-Entry
Target Gene NR1H3
Background The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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