Cat.No. : AD00214Z
Titer: ≥1x10^10 IFU/mL / ≥1x10^11 IFU/mL / ≥1x10^11 VP/mL / ≥1x10^12 VP/mL Size: 100 ul/500 ul/1 mL
Storage: -80℃ Shipping: Frozen on dry ice
| Cat. No. | AD00214Z |
| Target Gene | NR1H3 |
| Species | Human |
| Product Type | Adenoviral particle |
| Insert | NR1H3 |
| Titer | Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc. |
| Size | Varies lot by lot, for example, 250 ul, 500 ul, 1 mL etc. |
| Storage | Store at -80℃. Avoid multiple freeze/thaw cycles. |
| Shipping | Frozen on dry ice |
| Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots. | |
| Endotoxin | Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance. |
| Sterility | Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination. |
| Ad5 E1 Detection | All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination. |
| RCA Assays | Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources. |
| PFU Titering | All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells. |
| Gene Name | NR1H3 nuclear receptor subfamily 1, group H, member 3 [ Homo sapiens ] |
| Gene Symbol | NR1H3 |
| Synonyms | LXRA; LXR-a; RLD-1 |
| Gene Description | nuclear receptor subfamily 1, group H, member 3 |
| Gene ID | 10062 |
| UniProt ID | Q8IW13 |
| mRNA Refseq | NM_001130102.2 |
| Protein Refseq | NP_001123574.1 |
| Chromosome Location | 11p11.2 |
| Function | DNA binding; cholesterol binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; protein heterodimerization activity; retinoid X receptor binding; sequence-specific DNA binding; steroid hormone receptor activity; sterol response element binding; transcription coactivator activity; transcription regulatory region DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding; |
| Pathway | Adipogenesis, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; |
| MIM | 602423 |
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The Human NR1H3 adenoviral particles from Creative Biogene exceeded all expectations in our recent experiments. The high transduction efficiency and stability ensured accurate results, which significantly advanced our cardiovascular research.
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