Mouse Ctnnb1 Insect Cell Lysate

Name: Mouse Ctnnb1 Insect Cell Lysate
SKU: CLOE-2591
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CLOE-2591 Host Cell : Baculovirus-Insect cell

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Cell Lysate Information

Gene Information

Cat. No.	CLOE-2591
Introduction	This cell lysate over-expresses mouse Ctnnb1 (Q02248) (Met1-Leu781) fused with N-terminal His/GST tag. Purification of target protein (s) from this cell lysate has been verified.
Target Gene	Ctnnb1
Host Cell	Baculovirus-Insect cell
Applications	Positive control for Western Blot (WB), antibody verification, protein purification
Storage	Upon receipt, store at 4°C, or prepare aliquots and store at -80°C. Multiple freeze-thaw cycles should be avoided.
Shipping	Ice package

Target Gene

CTNNB1

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

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