Monkey FLT3 Stable Cell Line - CHO-K1

The FLT3 (FMS-like tyrosine kinase 3) gene encodes a receptor tyrosine kinase that plays a pivotal role in hematopoiesis, particularly in the proliferation and differentiation of early hematopoietic cells. FLT3 is expressed on the surface of stem cells and early progenitor cells, and its activation leads to downstream signaling pathways that promote cell growth and survival. Mutations in the FLT3 gene, such as internal tandem duplications (ITDs) and point mutations, are associated with various hematological malignancies, including acute myeloid leukemia (AML). These mutations result in constitutive activation of the FLT3 receptor, leading to uncontrolled cell proliferation and resistance to apoptosis.

The CHO-K1 cell line, derived from the Chinese hamster ovary, is a widely used host for the production of recombinant proteins due to its high expression levels and well-characterized genetics. When engineered to stably express the FLT3 receptor, the CHO-K1 cell line becomes a valuable model for studying the function of FLT3 and its role in disease. This stable cell line allows researchers to investigate the effects of FLT3 activation, the impact of FLT3 inhibitors, and the mechanisms by which FLT3 mutations contribute to oncogenesis. It also serves as a platform for drug screening and the development of targeted therapies for FLT3-driven cancers.