Monkey CTLA4 Stable Cell Line - CHO-K1

Name: Monkey CTLA4 Stable Cell Line - CHO-K1
SKU: CSC-RO0202
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0202

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RO0202
Description	This cell line is engineered to stably overexpress the monkey CTLA4 in CHO-K1 cells.
Introduction	This cell line is constructed by transfection of monkey cytotoxic T-lymphocyte associated protein 4 (CTLA4) into CHO-K1, followed by stable cell selection. The expression of CTLA4 has been analyzed through flow cytometry.
Target Gene	CTLA4
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What type of monkey cells is the Monkey CTLA4 Stable Cell Line based on?

A: This cell line is established based on specific types of monkey cells (usually macaque or rhesus monkey cells), by stably integrating the CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4) gene into these cells.

How is the Monkey CTLA4 Stable Cell Line utilized in immunotherapy research?

A: This cell line can be used to study the immunoregulatory functions of CTLA4, especially in cancer immunotherapy and autoimmune disease research.

How does the CTLA4 expression level in the Monkey CTLA4 Stable Cell Line compare to natural expression?

A: The expression level of CTLA4 in this cell line is specially designed to mimic the natural expression level in immune cells in vivo, facilitating the study of CTLA4 function under physiological conditions.

What is the main use of the Monkey CTLA4 Stable Cell Line in drug screening?

A: It is primarily used for screening and evaluating the effects of small molecule drugs, antibodies, or other therapeutic agents targeting CTLA4, especially in anti-tumor immunotherapy.

What are the advantages of using this cell line for CTLA4-related signaling pathway research?

A: Due to the stable expression of the CTLA4 gene, this cell line is particularly suitable for studying the activation and regulation of CTLA4 signaling pathways and their roles in immune responses.

How is the biosafety of the Monkey CTLA4 Stable Cell Line assessed?

A: Its biosafety must be comprehensively assessed through cytotoxicity tests, pathogen detection, and genetic stability testing.

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