Human PPARA adenoviral particles

Name: Human PPARA adenoviral particles
SKU: AD12662Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD12662Z

Storage : -80℃ Shipping : Frozen on dry ice

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD12662Z
Description	Adenovirus with ORF of peroxisome proliferator-activated receptor alpha (PPARA), transcript variant 5.
Gene	PPARA
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	PPARA peroxisome proliferator-activated receptor alpha [ Homo sapiens ]
Gene Symbol	PPARA
Synonyms	PPAR; NR1C1; hPPAR; PPARalpha
Gene Description	peroxisome proliferator-activated receptor alpha
GeneID	5465
Uni ProtID	F1D8S4
mRNA Refseq	NM_001001928.2
Protein Refseq	NP_001001928.1
Chromosome Location	22q13.31
Function	DNA binding; RNA polymerase II repressing transcription factor binding; drug binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid binding; protein binding; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; ubiquitin conjugating enzyme binding; zinc ion binding;
Pathway	Activation of Gene Expression by SREBP (SREBF), organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem;
MIM	170998

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