Human CACNA1C adenoviral particles

Name: Human CACNA1C adenoviral particles
SKU: AD02876Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD02876Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD02876Z
Description	Adenovirus with ORF of calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C), transcript variant 11.
Gene	CACNA1C
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit [ Homo sapiens ]
Gene Symbol	CACNA1C
Synonyms	TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
Gene Description	calcium channel, voltage-dependent, L type, alpha 1C subunit
GeneID	775
Uni ProtID	Q13936
mRNA Refseq	NM_001129838.1
Protein Refseq	NP_001123310.1
Chromosome Location	12p13.3
Function	alpha-actinin binding; calmodulin binding; protein binding; protein domain specific binding; protein phosphatase 2A binding; voltage-gated calcium channel activity;
Pathway	Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Alzheimers Disease, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem;
MIM	114205

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