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shRNA set against Mouse HCN1 (NM_010408.3)

For research use only. Not intended for any clinical use.

Cat. No. :   SHH310825

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Gene Information

Cat. No. SHH310825
Description The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr HCN1
Species Mouse
Report Gene GFP
Storage The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.
Target Gene Hcn1
Background Enables cAMP binding activity; identical protein binding activity; and monoatomic cation channel activity. Involved in cellular response to cAMP; potassium ion transmembrane transport; and regulation of postsynaptic membrane potential. Acts upstream of or within several processes, including apical protein localization; general adaptation syndrome, behavioral process; and neuronal action potential. Located in axon; dendrite; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Is expressed in brain and heart. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1). [provided by Alliance of Genome Resources, Feb 2025]
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