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Rat Hcn1 cDNA Clone(NM_053375.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013127

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Gene Information

Cat. No. CDFR013127
Description NativeORF clone of Rattus norvegicus hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) as transfection-ready DNA NM_053375.1
Product Type cDAN Clone
Gene Abbr Hcn1
Species Rat
Vector pCMV6Entry
Target Gene Hcn1
Background Enables cAMP binding activity; identical protein binding activity; and monoatomic cation channel activity. Involved in cellular response to cAMP; potassium ion transmembrane transport; and regulation of postsynaptic membrane potential. Acts upstream of or within several processes, including apical protein localization; general adaptation syndrome, behavioral process; and neuronal action potential. Located in axon; dendrite; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Is expressed in brain and heart. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1). [provided by Alliance of Genome Resources, Feb 2025]
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