Recombinant Human IGF-I R (C-6His)

Name: Recombinant Human IGF-I R (C-6His)
SKU: RP00581
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00581 Tag : C-6His

Expressed Region : Glu31-Asn932 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00581
Description	The Recombinant Human IGF-I R (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Glu31-Asn932 with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol Weight	103.7&81&22.7 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Glu31-Asn932
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA, 0.5% Tween-20, 5% Trehalose, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	IGF1R
Background	This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms	CD221 antigen; CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGF-IR; IGFR; insulin-like growth factor 1 receptor; JTK13

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