Recombinant Human GDF15 (N-Fc)

Name: Recombinant Human GDF15 (N-Fc)
SKU: RP00058
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00058 Tag : N-Fc

Expressed Region : Ala197-Ile308 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00058
Description	The Recombinant Human GDF15 (N-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Ala197-Ile308 with a Fc tag at the N terminus.
Species	Human
Tag	N-Fc
Mol Weight	38.1 KDa
Conjugate	Unconjugated
Format	Liquid
Expressed Region	Ala197-Ile308
Expression System	Human Cell
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH7.4
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	GDF15
Background	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Synonyms	GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; PDF; PDFGDF-15; PLAB; PLABNRG-1

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