Recombinant Cynomolgus GDF15 (N-8His-Flag)

Name: Recombinant Cynomolgus GDF15 (N-8His-Flag)
SKU: RP00063

Cat.No. : RP00063 Tag: N-8His-Flag

Expressed Region: Ala197-Val308 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00063
Description	The Recombinant Cynomolgus GDF15 (N-8His-Flag) is produced in our Human Cell expression system. The amino acid region expressed is Ala197-Val308 with a 8His-Flag tag at the N terminus.
Species	Cynomolgus
Tag	N-8His-Flag
Mol. Weight	14.5 KDa
Expressed Region	Ala197-Val308
Expression System	Human Cell
Format	Liquid
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Glycine-HCl, 10% Trehalose, 0.02% Tween80, pH3.0.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.

Target Gene	GDF15
Background	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Synonyms	Growth Differentiation Factor 15; Macrophage inhibitory cytokine 1; GDF-15; MIC-1; NAG-1; PLAB; PTGFB

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