Recombinant Human CLDN18 (N-8His)

Name: Recombinant Human CLDN18 (N-8His)
SKU: RP00461
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00461 Tag : N-8His

Expressed Region : Asp28-Leu76 Expression System : E.coli

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Product Information

Gene Information

Cat. No.	RP00461
Description	Recombinant Human CLDN18 (N-8His) is produced in our E.coli expression system. The amino acid region expressed is Asp28-Leu76 with a 8His tag at the N terminus.
Species	Human
Tag	N-8His
Mol Weight	19.7 KDa
Conjugate	Unconjugated
Format	Liquid
Expressed Region	Asp28-Leu76
Expression System	E.coli
Formulation	Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 0.1% Triton X-100, 10% glycerol, 0.1mM GSH, 0.01mM GSSG, pH 8.0.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	CLDN18
Synonyms	Claudin-18; CLDN18

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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

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