Biotinylated Human CLDN18 (N-6His, C-Avi)V2

Name: Biotinylated Human CLDN18 (N-6His, C-Avi)V2
SKU: RP00492
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00492 Tag : N-6His,C-Avi

Expressed Region : extracellular Expression System : E.coli

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Product Information

Gene Information

Cat. No.	RP00492
Description	Biotinylated Human CLDN18 (N-6His, C-Avi)V2 is produced in our E.coli expression system. The amino acid region expressed is extracellular with a 6His,C-Avi tag at the N terminus.
Species	Human
Tag	N-6His,C-Avi
Mol Weight	12.6 KDa
Conjugate	Biotinylated
Format	Liquid
Expressed Region	extracellular
Expression System	E.coli
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8M Urea, 150mM NaCl, 5mM β-ME, pH 8.5.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	CLDN18
Synonyms	Claudin-18; CLDN18

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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

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