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Poly(I:C)

For research use only. Not intended for any clinical use.
Cat.No.
VAR-024
Description
Poly (I:C), a synthetic double-stranded RNA (dsRNA) analog, is known to interact with toll-like receptor 3 (TLR3). Poly (I:C) can activate the nuclear transcription factor NF-kB as well as stimulate the production of type I interferons (IFNs) leading to cytokine secretion. It is a common tool for scientific research on the immune system.
Alias
Polyinosinic-polycytidylic acid
Product Type
Toll-like Receptor Agonists
Storage
Store at -20°C

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Q & A

Customer Reviews

Customer Q&As
Why can this product induce cytokine secretion?

A: This is because Poly(I:C) can activate the transcription factor NF-kB, and stimulate the production of type I interferons (IFNs), which leads to cytokine secretion.

Can using Poly(I:C) always enhance immune activity?

A: No, that's not the case. There are certain concentration and dosage requirements for using this product. Appropriate doses can enhance immune activity, while larger doses can lead to inhibitory effects.

How to detect the content and distribution of Poly(I:C) inside cells?

A: Poly(I:C) is an analog of synthetic double-stranded RNA (dsRNA), so anti-dsRNA antibodies can be used to detect its content and distribution.

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Customer Reviews
Suitable for in vitro experiments

We have successfully studied the effects of different doses of Poly I:C on immune cell activity and cytokines.

United States

01/02/2021

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