Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : PMRN-0139
| Cat. No. | PMRN-0139 |
| Description | The IL1B mRNA encodes the human interleukin 1 beta (IL1B) protein, a member of the interleukin 1 cytokine family. IL1B is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. |
| Gene Type | Other |
| RNA Type | mRNA |
| Gene Name | IL1B |
| Species | Homo sapiens (Human) |
| Alias | IL-1, IL1-BETA, IL1F2, IL1beta |
| Features |
• mRNA synthesized on error free sequence verified plasmid DNA template • 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP • Cap 1 Capping and poly-A tailed incorporated • Degrades the DNA template after RNA synthesis with DNase |
| Sequence | MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS |
| Storage | Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers. |
A: Human IL1B mRNA refers to human interleukin-1 β (Interleukin-1beta) messenger RNA molecule. IL1B is a cytokine secreted by cells, involved in regulating inflammation and immune responses.
A: Human IL1B mRNA encoded protein - interleukin-1 β, It is an important inflammatory mediator. It is involved in regulating the activation of immune cells, the occurrence and development of inflammatory reactions, and the development of some diseases.
A: Human IL1B mRNA is mainly expressed in immune cells, such as macrophages, Monocyte, lymphocytes, etc. In addition, some non immune cells such as epithelial cells and endothelial cells can also express IL-1B mRNA.
A: The expression of Human IL1B mRNA is influenced by various regulatory factors, including inflammatory mediators, cytokines, pathogen infections, and cellular stress. These regulatory factors can regulate the transcription and stability of IL1B mRNA by activating transcription factors and signaling pathways.
A: Human IL1B mRNA plays an important role in many inflammatory diseases, such as rheumatoid arthritis, Inflammatory bowel disease, autoimmune diseases, etc. It is also related to the occurrence and development of certain tumors.
A: Yes, some studies show that Human IL1B mRNA plays an important role in the occurrence and development of cardiovascular diseases. It is involved in the inflammatory reaction of Atherosclerosis, vascular endothelial dysfunction and other processes.
A: The commonly used methods for detecting Human IL1B mRNA include real-time quantitative PCR, Northern blotting, in situ hybridization, etc. These methods can quantitatively or qualitatively measure the expression level of IL1B mRNA.
A: Yes, some drugs can inhibit the expression of Human IL1B mRNA, such as IL-1 receptor antagonists (IL-1RA) and IL-1 β Antibodies, etc. These drugs can be used to treat diseases related to IL1B overexpression.
A: Due to its important role in various inflammatory diseases, Human IL1B mRNA is considered a potential therapeutic target. Some drugs have been developed to inhibit the expression of IL-1B or the activity of its receptors for the treatment of related diseases.
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