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Human IGF1R mRNA

For research use only. Not intended for any clinical use.
Cat.No.
PMRN-0112
Description
The IGF1R mRNA encodes the human insulin like growth factor 1 receptor (IGF1R) protein. IGF1R plays a critical role in transformation events.
Alias
CD221, IGFIR, IGFR, JTK13
Features
• mRNA synthesized on error free sequence verified plasmid DNA template
• 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP
• Cap 1 Capping and poly-A tailed incorporated
• Degrades the DNA template after RNA synthesis with DNase
Sequence
MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC
Species
Homo sapiens (Human)
Storage
Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

Publications

Q & A

Customer Reviews

Customer Q&As
What is human IGF1R mRNA?

A: Human IGF1R mRNA refers to the Messenger RNA (mRNA) molecule of the Insulin-like growth factor 1 receptor (IGF1R) in the human body.

What is the function of IGF1R mRNA?

A: The function of IGF1R mRNA is to code IGF1R protein, which is a Receptor tyrosine kinase and participates in the regulation of cell growth, differentiation and survival.

In which tissues is IGF1R mRNA expressed?

A: IGF1R mRNA is widely expressed in various tissues of the human body, including the liver, kidneys, lungs, heart, muscles, etc.

What factors regulate the expression of IGF1R mRNA?

A: The expression of IGF1R mRNA is regulated by various factors, including growth factors, hormones, cellular environment, and gene regulatory factors.

Are mutations in IGF1R mRNA associated with certain diseases?

A: Yes, IGF1R mRNA mutations are associated with some diseases, such as certain types of cancer, obesity and diabetes.

How does the expression level of IGF1R mRNA affect cell growth and proliferation?

A: The expression level of IGF1R mRNA affects cell growth and proliferation, with high expression levels usually associated with enhanced cell growth and proliferation, while low expression levels are the opposite.

What is the role of IGF1R mRNA in tumors?

A: IGF1R mRNA plays an important role in tumors, as it is involved in regulating the proliferation, metastasis, and drug resistance of tumor cells.

Is the expression of IGF1R mRNA related to age?

A: The expression of IGF1R mRNA is age related, and the expression level of IGF1R mRNA may change with age.

Is there any research evidence suggesting that mutations in IGF1R mRNA are associated with drug resistance?

A: Yes, some studies suggest that mutations in IGF1R mRNA may be associated with drug resistance, which is of great significance for tumor treatment.

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Customer Reviews
Fast & Convenient

Very simple and fast to obtain IGF1R mRNA, one vial can be used for a long time.

United States

08/15/2021

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