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Cat.No. : CSC-BS0006 Host Cell: CHO-K1
| Cat. No. | CSC-BS0006 |
| Description | This cell line is engineered to stably produce Adalimumab which is a monoclonal antibody against human TNF. |
| Biosimilar | Adalimumab |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Biosimilar Development 2. Large-Scale Biomanufacturing 3. Preclinical Research 4. Drug Development and Testing |
| Growth Conditions | 37° C, 5% CO2 |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Adalimumab is a disease-modifying antirheumatic drug (DMARD) and monoclonal antibody that works by inactivating tumor necrosis factor-alpha (TNFα).
A: Adalimumab works by selectively binding to a protein called tumor necrosis factor-alpha (TNF-α). By binding to TNF-α, adalimumab inhibits its activity and reduces inflammation.
A: Pembrolizumab has shown promising results in treating many types of cancer, including melanoma, non-small cell lung cancer, and bladder cancer.
A: Yes. Adalimumab is a specific inhibitor of TNF-α, and does not affect other cytokines or immune cells. This makes it a targeted therapy with fewer side effects compared to non-specific immunosuppressive drugs that affect multiple pathways.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
Great! To produce a therapeutic dose of Adalimumab, a stable cell line is needed.
United States
02/23/2023
The adalimumab stable cells are grown in suspension culture, which not only simplifies the purification process but also reduces the risk of contamination. I recommend it.
United States
04/11/2023
The stable cell line that produces functional pembrolizumab using CHO-K1 cells is a significant step forward in the fight against cancer. This helps a lot with my project.
Germany
08/09/2023
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