Rat Xiap cDNA Clone(NM_022231.2)

Name: Rat Xiap cDNA Clone(NM_022231.2)
SKU: CDFR011916
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011916

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Product Information

Gene Information

Cat. No.	CDFR011916
Description	NativeORF clone of Rattus norvegicus X-linked inhibitor of apoptosis (Xiap) as transfection-ready DNA NM_022231.2
Product Type	cDAN Clone
Gene Abbr	Xiap
Species	Rat
Vector	pCMV6Entry

Target Gene

XIAP

Background

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

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