Panoply™ Human XIAP Knockdown Stable Cell Line

Name: Panoply™ Human XIAP Knockdown Stable Cell Line
SKU: CSC-DC017567
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC017567

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-DC017567
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	XIAP
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	XIAP X-linked inhibitor of apoptosis [ Homo sapiens ]
Gene Symbol	XIAP
Synonyms	XIAP; X-linked inhibitor of apoptosis; API3, baculoviral IAP repeat containing 4 , BIRC4; baculoviral IAP repeat-containing protein 4; hILP; X-linked IAP; IAP-like protein; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing 4; X-linked inhibitor of apoptosis protein; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; FLJ26913;
GeneID	331
Uni ProtID	P98170
mRNA Refseq	BC032729
Chromosome Location	Xq25
Function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ligase activity; metal ion binding; peptidase inhibitor activity; protein binding; ubiquitin-protein ligase activity; zinc ion bindin
Pathway	Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem;
MIM	300079

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Q & A

Customer Reviews

Customer Q&As

What is XIAP？

A: The X-linked inhibitor of apoptosis protein (XIAP) is a newly identified major member of the IAP family.

What is the role of XIAP?

A: XIAP is the most potent inhibitor of apoptosis in the IAP family, directly inhibiting caspases and regulating apoptosis in multiple ways.

What is the relationship between XIAP and tumours?

A: XIAP gene is overexpressed in most tumour cell lines and its expression is closely associated with tumour progression, recurrence, prognosis and resistance to tumour chemotherapy.

What is the composition of the XIAP gene?

A: The human XIAP is a relatively typical IAPs, consisting of three BIR structural domains and three RING structures.

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