Mouse XIAP ORF clone(NM_009688.2)

Name: Mouse XIAP ORF clone(NM_009688.2)
SKU: CDCL186789
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL186789

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Product Information

Gene Information

Cat. No.	CDCL186789
Description	ORF Clone of Mus musculus X-linked inhibitor of apoptosis DNA.
Product Type	ORF clone
Gene Abbr	XIAP
Species	Mouse
ORF Size	1491bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

XIAP

Background

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

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