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Rat Sqstm1 ORF Clone(NM_181550.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR382029

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Gene Information

Cat. No. CDCR382029
Product Type ORF Clone
Gene Abbr Sqstm1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 705 bp
Vector pCMV6-Entry
Target Gene SQSTM1
Background This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
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