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Rat Rasgrf1 ORF Clone(NM_001105753.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR372575

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Gene Information

Cat. No. CDCR372575
Product Type ORF Clone
Gene Abbr Rasgrf1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 534 bp
Vector pCMV6-Entry
Target Gene RASGRF1
Background The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
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