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Rat Npc1l1 cDNA Clone(NM_001002025.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001190

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Gene Information

Cat. No. CDFR001190
Description NativeORF clone of Rattus norvegicus NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (Npc1l1) as transfection-ready DNA NM_001002025.1
Product Type cDAN Clone
Gene Abbr Npc1l1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene NPC1L1
Background The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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