Mouse Npc1l1 ORF Clone(NM_207242.2)

Name: Mouse Npc1l1 ORF Clone(NM_207242.2)
SKU: CDCR277012
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR277012

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Product Information

Gene Information

Cat. No.	CDCR277012
Product Type	ORF Clone
Gene Abbr	Npc1l1
Species	Mouse
Tag	C-terminal Myc-DDK
ORF Size	4002 bp
Vector	pCMV6-Entry

Target Gene

NPC1L1

Background

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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