Mouse Npc1l1 cDNA Clone(NM_207242.2)

Name: Mouse Npc1l1 cDNA Clone(NM_207242.2)
SKU: CDFL008490
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL008490

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Product Information

Gene Information

Cat. No.	CDFL008490
Product Type	cDNA clone
Gene Abbr	Npc1l1
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

NPC1L1

Background

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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