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Rat Mlh1 cDNA Clone(NM_031053.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR012529

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Gene Information

Cat. No. CDFR012529
Description NativeORF clone of Rattus norvegicus mutL homolog 1 (E. coli) (Mlh1) as transfection-ready DNA NM_031053.1
Product Type cDAN Clone
Gene Abbr Mlh1
Species Rat
Vector pCMV6Entry
Target Gene MLH1
Background The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
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