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Human MLH1 Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0235
Abbr
LN428 Glioma-HuMLH1 Knockdown
Alias
MLH1,FCC2,HNPCC,HNPCC2,COCA2,hMLH1,MGC5172,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

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