Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)

Human MLH1 Knockdown Cell Line-LN428 Glioma

See other products for MLH1
Cat.No.
CSC-RK0235
Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
MLH1
Synonyms
MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172;
Gene ID
MIM
UniProt ID
P40692
Chromosome Location
3p22.3
Pathway
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem;
Function
ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding;

Quick Inquiry

Please input "biogene" as verification code.

MLH1 Related Products

Transfected Stable Cell Lines

By Gene symbol(3)
+Expand
By Species(3)
+Expand

Premade Virus Particles

By Gene symbol(3)
+Expand
By Species(3)
+Expand

Clones

By Gene symbol(15)
+Expand
By MicroRNA Accession No.(2)
+Expand

Contact Us

USA

Europe

CBpromise   

Our promise to you:
Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE
CONTACT US TO ORDER