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Human MLH1 ORF clone (NM_001258271.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL132969

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Product Information

Gene Information

Cat. No. CDCL132969
Description Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 5, mRNA.
Product Type ORF clone
Gene Abbr MLH1
Gene Name MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ]
Species Human
ORF Size 2064bp
Format purified plasmid
Vector pDONR
Warning Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.
Gene Name MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ]
Gene Symbol MLH1
Synonyms MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172;
Gene ID 4292
Uni Prot ID P40692
m RNA Refseq BC006850
Chromosome Location 3p22.3
Function ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding;
Pathway BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem;
MIM 120436
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