Rat Lrp6 cDNA Clone(NM_001107892.1)

Name: Rat Lrp6 cDNA Clone(NM_001107892.1)
SKU: CDFR007539
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR007539

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Product Information

Gene Information

Cat. No.	CDFR007539
Description	NativeORF clone of Rattus norvegicus low density lipoprotein receptor-related protein 6 (Lrp6) as transfection-ready DNA NM_001107892.1
Product Type	cDAN Clone
Gene Abbr	Lrp6
Species	Rat
Vector	pCMV6Entry

Target Gene

LRP6

Background

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

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