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Rat Lrp6 ORF Clone(NM_001107892.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR374562

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Gene Information

Cat. No. CDCR374562
Product Type ORF Clone
Gene Abbr Lrp6
Species Rat
Tag C-terminal Myc-DDK
ORF Size 3705 bp
Vector pCMV6-Entry
Target Gene LRP6
Background This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
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