Rat ERBB3 ORF clone(NM_017218.2)

Name: Rat ERBB3 ORF clone(NM_017218.2)
SKU: CDCL184102
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL184102

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Product Information

Gene Information

Cat. No.	CDCL184102
Description	ORF Clone of Rattus norvegicus v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) DNA.
Product Type	ORF clone
Gene Abbr	ERBB3
Species	Rat
ORF Size	4020bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

ERBB3

Background

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

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