Rat CCR5 ORF clone(NM_053960.3)

Name: Rat CCR5 ORF clone(NM_053960.3)
SKU: CDCL183151
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL183151

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Product Information

Gene Information

Cat. No.	CDCL183151
Description	ORF Clone of Rattus norvegicus chemokine (C-C motif) receptor 5 DNA.
Product Type	ORF clone
Gene Abbr	CCR5
Species	Rat
ORF Size	1065bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

CCR5

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

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